Reproduction in Humans

(IB Topic D3.1)

Essential Idea(s): Formation of haploid gametes is required for sexual reproduction. Pregnancy and birth are then regulated by interactions between maternal and fetal hormones and systems.

Unit Length: 3 Lessons (+4 AHL)

  Guiding Questions

◊ How does asexual or sexual reproduction exemplify themes of change or continuity?

◊ What changes within organisms are required for reproduction?

IB Statement(s) and Objective(s)

 

D3.1.2: Role of meiosis and fusion of gametes in the sexual life cycle

  • Outline the roles of meiosis and fertilization in the sexual life cycle

 

D3.1.3: Differences between male and female sexes in sexual reproduction

  • Compare motility, size, energy reserves and production rate of male and female gametes of plants and animals

 

D3.1.4: Anatomy of the human male and female reproductive systems

  • Annotate diagrams of the male and female reproductive systems to show names of structures and their functions

 

D3.1.5: Changes during the ovarian and uterine cycles and their hormonal regulation

  • Define ovarian cycle, uterine cycle and menstrual cycle
  • State the source and location of action of hormones in the menstrual cycle: FSH (follicle-stimulating hormone), LH (luteinizing hormone), estrogen, progesterone
  • Detail the key events in the menstrual cycle

 

D3.1.6: Fertilization in humans

  • Describe the process of fertilization in humans
  • Outline the events of joint mitosis following fertilization

 

D3.1.7: Use of hormones in in vitro fertilization (IVF) treatment

  • Define in vitro fertilization (IVF)
  • Outline the process of in vitro fertilisation including down-regulation, superovulation, harvesting, fertilization and implantation

 

Additional Higher Level Topics

D3.1.13: Control of the developmental changes of puberty by gonadotropin-releasing hormone and steroid sex hormones

  • Define puberty
  • Explain the control of puberty by GnRH and the hormones LH and FSH
  • List secondary sexual characteristics triggered by estrogen and progesterone at puberty
  • List secondary sexual characteristics triggered by testosterone at puberty

 

B2.3.10: Adaptations of sperm and egg cells

  • Describe the structural and functional adaptations of sperm and egg cells

 

D3.1.14: Spermatogenesis and oogenesis in humans

  • Define oogenesis and spermatogenesis
  • Compare the processes of spermatogenesis and oogenesis
  • Outline the processes involved in spermatogenesis within the testes
  • Outline the processes involved in oogenesis
  • Outline the development of polar bodies in female gametes

 

D3.1.15: Mechanisms to prevent polyspermy

  • Define polyspermy and explain why it is detrimental to an organism

 

D3.1.16: Development of a blastocyst and implantation in the endometrium

  • Define zygote, blastocyst and fetus
  • Outline embryonic development from zygote to blastocyst

 

D3.1.17: Pregnancy testing by detection of human chorionic gonadotropin secretion

  • List the source, target and function of hCG (as related to the maintenance of pregnancy)
  • Explain how a pregnancy test strip works, including the role of free and immobilized monoclonal antibodies

 

D3.1.18: Role of the placenta in fetal development inside the uterus

  • Describe the main functions of the placenta
  • List the direction and mechanism of transport between maternal and fetal blood for CO2, O2, glucose, urea, antibodies and water in the placenta

 

D3.1.19: Hormonal control of pregnancy and childbirth

  • List the source, target and function of estrogen and progesterone as related to pregnancy
  • List the source, target and function of estrogen and oxytocin as related to the birth process

 

D3.1.20: Hormone replacement therapy and the risk of coronary heart disease

  • Define hormone replacement therapy (HRT)
  • Discuss the use of hormone replacement therapy in postmenopausal women
  • Evaluate the relationship between HRT and incidence of coronary heart disease
  • NOS: Explain how spurious correlations can lead to false conclusions of cause-and-effect relationships
Activities: = podcast / = inquiry 5 / = Write it Ӕ = The academy  / = Read it

 

ⓟ/ⓦ: Radiolab – The Primordial Journey (💁/ 👭 max 3)

Listen to this RadioLab podcast on reproduction (skip ahead to 1:55 to begin). Together with your fellow podcasters, respond by discussing: 1) The basics of gametogenesis – what are gametes, and how do they form?; 2) If anything from the podcast surprised you.

 

ⓟ/ⓦ: Reproduction Revolution – Turning Skin Cells into Sperm/Egg (💁/ Podcast: 👭 max 3)

Biotech research is on the brink of being able to do something quite amazing: take a skin cell, induce it to reverse differentiate, then differentiate it into a sperm or egg cell. Connect your knowledge of stem cells with reproduction, and take a glimpse into the future of biotechnology. Respond by answering: 1) How do sperm/egg cells typically develop; 2) What are induced pluripotent stem cells?; and 3) Why would it be useful to reverse engineer a skin cell into a reproductive cell?

 

ⓟ/ⓦ: “The Pill”…Now for Women AND Men (💁)

Imagine a contraceptive pill for both men and women. That reality might not be too far off. Read about researchers efforts to produce a drug that can shut down the sperm’s ability to swim inside the uterus, then respond by discussing: 1) What capacitation is during fertilization; 2) How this drug might potentially affect capacitation; and 3) How you think society might respond to the idea of both men and women being “on the pill”.

 

/: The Mystery of “Semi-Identical Twins”  (💁/ 👭 max 3)

A recent case swept the medical community when a routine ultrasound + blood test revealed twins that were neither identical nor fraternal…but somewhere in between. Read about the case and discuss: 1) What typically happens to embryos in identical and fraternal twins; and 2) What unique steps happened in this case; and 3) What made the case a unique example of polyspermy.

 

/(+NOS): Woops?! Does ‘the pill’ make men infertile?

(💁/ Podcast: 👭 max 3)

Science sometimes has unintended consequences. As effective as the female contraceptive pill has been, its widespread use has proven to be a common suspect in problems ranging from “intersex fish” to infertile human males. Some suggest that the pill might be responsible for the recent “male fertility crisis” – the incredibly rapid rate of decline in both quality and quantity of male sperm in recent decades. Are these accusations misguided? Did we misstep in our use of the female contraceptive pill? Are alarmists spoiling a perfectly good scientific invention? How should science approach the possibility of unforeseen consequences? Respond to these problems, using ideas from 11.4.A1.

 

ⓟ/ⓦ: The 4-year old trapped inside a 14-year old’s body (💁)

What’s the earliest onset for puberty? If you’re unlucky enough to have a mutated luteinizing hormone gene, it can happen as early as 2 years old…which obviously presents some problems. Read about one such case, and discuss: 1) How do hormones regulate life phases, e.g. puberty?;  2) What exactly do hormones do during puberty? (use specific terminology from the unit);  3) How can single mutations result in completely unique lives and medical cases, as described in the story?; 4) If you think screening for such cases should be mandatory for expecting parents.   

 

/: TED Talk: The birds and the bees are just the beginning

(💁/ 👭 max 2)

People often know very little about sex, and even less about the evolution of sex in the natural world. From detachable penises to “traumatic insemination”, there are wildly strange sex habits in the animal kingdom. Learn about some of them here, then discuss: 1) How have different approaches to sex evolved in the animal kingdom?;  2) What is meant by the expressions, “eggs are expensive, and sperm is cheap?” and how do these influence the evolution of sex? 

Just for Extra Practice:  Menstrual Whiteboarding